ABSTRACT
Species of the genus Leishmania parasitize mammals and have life cycles that alternate between vertebrate and invertebrate hosts. Most species develop in a hematophagous arthropod and infect a specific vertebrate host that may belong to diverse orders and families. Visceral leishmaniasis is a chronic zoonosis with a wide geographic distribution, affecting 350 million people globally, mostly in areas with a high risk of infection. In Brazil, this disease not only has a high incidence but is also expanding to new areas, both in urban centers and rural areas, including territories with tribal communities, due to increasing human intervention. The objective of this study was to perform cathepsin L-like gene-based molecular diagnosis of Leishmania infantum in the indigenous Tapirapé ethnic group in the state of Mato Grosso. From the 372 individuals assessed, only 0.8% (3/372) tested positive for L. infantum, all from the same village (Urubu Branco). Despite the small number of infected individuals, this study demonstrates the first human cases of Leishmania infantum infection in this population, suggesting the need for regular monitoring of visceral leishmaniasis in the area and leading to a broad discussion on the planning and implementation of public health measures for the indigenous population, while respecting their distinctive territories and culture.
ABSTRACT
Chinese Medicine uses acupuncture points K-3 (Taixi), Li-3 (taichong), S-36 (Zusanli), Ren-4 (Guanyuan)and Ren-6 (Qihai) to enhance the individual's general energy, improving capacity to physical efforts, and the body threshold to fadigue. We studied the influence of these specific points on physical performance capacity (PPC) and physiological responses to excercise (PRE). Material - We assigned 27 healthy men at random to three groups: acupuncture (A), acupuncture sham (S) and control group (no acupuncture (N). Methods - Performance was determined through of a spiroergometric test was carried out at the beginning and at the end of five sucessive daily sessions, consisting of 20 minutes of electroacupuncture (EA) of the selected points. They performed a continuous incremental (25 watts/min) test until exhaunstion in bicycle ergometer (Cibex the Bike). Respiratory and metabolic variables were calculated every 20s during excercise by a computerized spiroergometric system (Vista CX). The heart was obtained by telemetry (Polar), The rate of perceived exertion (RPE) was measured by the Borg's revised scale. Results - The results before and after treatment were compared in these conditions: rest (R); moderate exercise (M); at the anaerobic threshold (AT); intense exercise (I); maximal exercise (MX) and recovery (RC). The subjects from group A didn't increase the maximal performance capacity neither the PPC at AT. Respiratory, cardiovascular responses and movement economy in M, AT, I and MX didn't improve in these group. We detected a positive effect of EA only in RPE during M. There was no differences between tests in groups S an N. Conclusion - These results suggest that the EA in studied conditions isn't effective to increase PPC or improve PRE.